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Research suggests that nicotine is a cause of insulin resistance

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Because a combination of a nicotine replacement therapy and an antidepressant is dramatically more effective than a single therapy alone, the government's report on treating tobacco dependence urges that "all patients attempting to quit should be encouraged to use effective pharmacotherapies for cessation except in the presence of special circumstances." First-line therapies for smoking cessation are (a) nicotine replacement therapy, which is available in many forms (gum, patches, lozenges, nasal spray, and an oral inhaler), and (b) a psychotropic drug (bupropion/Zyban)

Physical and Mental Symptoms During Withdrawal When smokers cease nicotine consumption , they experience a complex array of physical and psychological withdrawal symptoms that typically manifest within 4-24 hours